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Sell Aclesin - Antiarrythmic API ( Substance ) (October 14, 2006)
ACLESIN is a mixture of alkaloids, derived from roots of the Aconitum leucostomum plant. As antiarythmic drug, ACLESIN improves auricular and ventricular disturbances of heart rhythm, caused by different mechanisms. ACLESIN depress conductance of impulses across auricles and Hiss-Pourkinje system, does not influence the conductivity across atrioventricular node; does not induce negative inotropic effect, arterial hypotension and cholinolytic action. ACLESIN exerts local anesthetic, analgetic, anti-inflammatory and sedative actions. Administered per os, drug acts after 30-50 min intervals and therapeutic effect lasts for nearly 8 hours. Repeated application does not lead to diminishing of antiarrhythmic effect. The drug is prescribed for patients with ventricular and supraventricular extrasystolias, auricular paroxysmal flutter, paroxysmal supraventricular and ventricular tachycardia, for Wolf-Parkinson-White syndrome. The drug is also used for arrhythmias that accompany the myocardial infarction and different chronic circulatory diseases. Having compared with existing antiarrhythmic drugs, ACLESIN is more effective drug for treatment of patients with chronic and dangerous for life ventricular tachyarythmias. Preparation is more effective than Quinidine, Disopyramide, Cordarone (Amiodarone), Aethmozine and Aethacizine. ACLESIN, in comparison to the other drugs, has notable advantages, as it can also be used in cases of sinus bradycardia syndrome of sinonodal weakness, syndrome of widety of interval Q-T and on phone of low arterial pressure. Long-term application of ACLESIN does not result in tachyphylaxia, arythmogeneity and other cardiotoxic effects, toxic influences on inner organs, hemapoetic system and sensation organs. For the patients with cardiac insufficiency ACLESIN practically does not influence on contractile functions of myocard, which is important advantage when compared to other antiarrhythmic drugs. Available in substance, and tablets.
[Related Categories: Pharmaceutical Chemicals ]
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Desoxypeganine Hydrochloride API (Substance) (October 14, 2006)
Desoxypeganine hydrochioride is chloride salt of the alkaloid desoxypeganine from the Peganum harmala plant. Desoxypeganine hydrochioride is an inhibitor of cholinesterase. Its anticholinesterase effect is reversible. It also has a direct stimulative influence on cholinoreceptors. As the fermentative activity of cholinesterase is depressed and the cholinoreceptors sensitiveness is raised, the transmission of nervous impulses in the cholinoreceptive synapses occurs easily. The drug restore the neuromuscular conductivity, broken by the antidepolarizing relaxants, increases the vitality of the smooth musculature and intensifies a salivation. Desoxypeganine hydrochioride is prescribed to the patients suffering from the damaged peripheral nervous system of various etiology; it is effective for diseases, accompanied by the affections of the front horns of the spinal cord; it is used for the treatment of the broken brain blood circulation consequences; it is also effective for myasthenia and myopathy-like syndromes of various genesis. For the last few years Desoxypeganine is used as drug against smoking. Desoxypeganine hydrochioride is the same as Galanthamine hydrobromide, Neostigmine methylsulfate and Eserinum by principal pharmacological properties, but it differs by exerting high anticholinesterase activity and lower toxicity. Desoxypeganine in 6 times is more effective than Neostigmine methylsulfate. The drug has got a good absorption ability by hypodermic and Intramuscular injection; it easily penetrates through the blood-brain barrier and is excreted by kidneys in the form of the weak active oxidized products. Produced in the form of pure substance, tablets (0,05 g) and in 2 ml ampules of 1% water solution. Additional information Approval of Ministry of Health of the USSR N377 (June 26,1989) for practical use in all Republics of former USSR.
[Related Categories: Pharmaceutical Chemicals ]
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Sell Cytisine API ( Substance ) (October 14, 2006)
Cytisine - respiratory analeptic. Composition cytisine is quinolizidine alkaloid present in the seeds of thermopsis lancefljata. Cytisine is related to compounds of "ganglionic activity". The alkaloid are used as respiratory analeptic. For the last few years cytisine is used as drug destined for aversion from smoking. Cytisine invokes irritation at ganglia of vegetative nervous system and related organs: Chromaffin tissue of suprarenals and carotid bodies. Intrinsic to cytisine respiration activation is called by it reflectory stimulation of respiratory center, activated by impulsation from carotid bodies. Simultaneously the drug activates sympathetic nodes and paranephros and by this way increases arterial pressure. At reflectory respiratory block (at surgical operations; traumas and etc. ) it can be used as respiratory analeptic. Its pressor effect permits usage of the cytisine at shock and collaptic states; at respiratory and circulatory depression of patients with infection diseases and etc. The drug is contraindicated (in view of its pressor activity) for the patients with obvious atherosclerosis and hypertension, bleedings, edema of the lungs. Cytisin available in substance and also under the trade name cytitonum used as 0,15% -1,0 ml solution in ampoules. Clinical trials have been carried out in clinics of Russia, Ukraine and uzbekistan. Spc document 42-2791-91 (june 13,1991) of the pharmacological committee of Russia.
[Related Categories: Pharmaceutical Chemicals ]
[Related Keywords: None ]

Sell Galanthamine Hydrobromide API ( Substance ) (October 14, 2006)
Galanthamine hbr - inhibitor of cholinesterase. Galanthamine hydrobromide is bromhydrate salt of the alkaloid galantaminum, isolated from the galantus voronovi, galantus nivalis) and ungernia victori. Galantamine hydrobromide is strong inhibitor of cholinestherase. Drug potentiates cholinomimetic effect of acetylcholine on cholinoreceptors, facilitates neuromuscular conductance that blocked by antidepolarising myorelaxants; increases a tone of smooth musculature and increases a secretion of digestive glands. The drug easily penetrates across blood-brain barrier and facilitates conductance of impulses in cholinergic synapses of cns. Galantamine hydrobromide is prescribed: For the motor and sensitive disturbances, combined with neuritis, polyneuritis, radiculitis; for residual manifestation, caused by disturbances of brain circulation; for psychogenic impotency and pathology of nervous conductance; at the recovery period after acute poliomyelitis and in cases of children's cerebral palsy, galantamine restores the motor activity. Galantamine hydrobromide is not advised in cases of epilepsy, hyperkinesias, bronchial asthma, bradycardia, ulcers of stomach and duodenum. Galanthamine is available in substance and in ampoules of 1,0 ml of 0,25; 0,5 and 1,0% solutions.
[Related Categories: Pharmaceutical Chemicals ]
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Sell Tefestrol API ( Substance ) (October 14, 2006)
Tefestrol - is a mixture of the sesquiterpene complex esters ferutinine (90%) and tenuferidine (10%), isolated from the plant ferula tenuisecta. Tefestrol exhibits estrogen-like action; the activity is the similar to synthetic estrogens. Administration of tefestrol induces enhancement proliferation of vaginal and endometrial mucus layers; stimulates feebly marked secondary female sex signs. Drug improves common disturbances caused by deficiency of sex glands activity. The preparation activates synthesis and secretion of luteinizing and folliculostimulating hormones of hypophysis and stimulates ovulation process. Tefestrol is prescribed for the treatment of pregnant women, in gynecology for the treatment of infertility and at the climacterium period. It is used for eradication of retardation of sexual maturation, disturbances of menstrual cycle, dysfunctional menorrhagias, feminal climax, interruption of pregnancy, infertility of endocrine genesis; for preparation and pathologic tendency of labor. Low toxicity of drug and soft therapeutic effect result in its long-term usage, available with hestagens, as a substitute therapy for many gynecologic diseases. In comparison with known drugs exerting the same effect such as sinestrol (hexestrol), diethylstilbestrol and ethenylestradiol. Tefestrol is natural compound from medicinal plant. It does not influence arterial pressure, it practically does not cause changes in the system of a hemostasis, does not change secretion endogenic estrogens. Its therapeutic dozes has no embryotoxicity. Due to its none-toxicity the preparation guarantees safe application in children's gynecology. Available as substance and tablets, containing 0,005g of tefestrol. By protocol no7 (april 11,1986) of the pharmacological committee of ministry of health of the ussr the tefestrol has been approved to practical use. Clinical trials of the drug have been carried out among the 409 patients of the research centre on health protection of mother and child (moscow, ussr) and among about 3000 patients in clinics of uzbekistan.
[Related Categories: Pharmaceutical Chemicals ]
[Related Keywords: None ]

Sell Medamine, Albendazole, Phenasal - Antihelmintes API ( Substance ) (October 14, 2006)
Helminthicide of wide spectrum action. They are effective against intestinal hemathelminthes. Medamine is used for the treatment of ascariasis, trichocephaliasis, enterobiasis, strongyloidiasis, ankylostomiasis. Albendazole - for treatment of ascariasis, trichocephaliasis, enterobiasis, strongyloidiasis, ankylostomiasis and other nemathodes. Phenasal - for treatment of teniarchosis, difillobotriosis, teniosis, hymenolepiasis and cestodosis. Medamine and Albendazole can be successfully used instead of such drugs as Vermoxum (Mebendazole), Carbendazim and Decaris (Levamisolum).
[Related Categories: Drugs & Medications ]
[Related Keywords: None ]

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